Why Does IVF Fail Even with Good Embryo
- Mediworld Fertility
- Mar 26, 2021
Reports suggest that only 30-35% of the IVF treatments in India are successful. While the statistics might seem daunting, this doesn’t mean that you should rule out IVF treatments from your list of choices completely. Knowing about the facts and having a transparent understanding of the procedure helps you make better decisions when it comes to the treatment and also be ready to accept the results, whatever they are.
Even with perfectly healthy embryos, some couples have had to face an unsuccessful IVF treatment. This is primarily because the success rate doesn’t just depend on the embryos. There are a few accessory factors that influence the results.
Here, we will discuss why IVF fail even with good embryos and what you can do to combat those shortcomings for a successful conception.
Table of Contents
(Feel free to skip ahead if a topic catches your eye)
- Female’s Age
- Genetic and Chromosomal Effec
- Embryo Implantation Failure
- IVF Cycle Cancellation
- What to do After IVF Fails?
1. Female’s Age
Ageing has one of the primary impacts on a woman’s fertility. With age, both the quality and the quantity of the woman's egg reserve start declining. Ageing has lasting impacts on the ovarian reserve in women. So, it goes without saying that despite having a successful extraction of the eggs, chances of an unsuccessful IVF are still possible.
Even a conducted study found that the chances of live birth from a single round of egg retrieval in women aged 34 and less was 52.4%, while the rate decreased drastically in women between the age of 35-44 years. Older women also had a heightened risk of miscarriage following their IVF treatment.
2. Genetic and Chromosomal Effect
Several times, even after a successful extraction of embryos for IVF, couples have experienced failed IVF treatment due to chromosomal abnormalities in the embryo. Some of these genetic and chromosomal defects are either present already in the embryo of the female or sometimes developed during the fertilization process in the lab.
Women above the age of 30 are most at risk of having chromosomal defects in the embryos. The issues further get worse with age.
One of the most common genetic or chromosomal impairments that happen is aneuploidy that results in few or too many chromosomes in the cell. Such a condition contributes to heightened risks of miscarriages or failed IVF implantation.
There are a few other types of chromosomal polymorphisms that result in failed IVF treatment. It is always crucial to consult your fertility specialist and discuss all these complications before undergoing the treatment.
3. Embryo Implantation Failure
There are several factors that can result in a failed embryo implantation. Even some of the healthy-looking embryos that are successfully fertilized in the lab can have issues with implanting themselves into the woman’s uterus.
Not just once, some women often experience repeated implantation failure during their IVF treatment, a condition known as Recurrent Implantation Failure. A woman undergoing such fertility treatment needs to undergo three or more failed implantations to consider their body undergoing an Embryo Implantation Failure.
There are two primary reasons that can lead to failed implantation - chromosomal defects in the embryo or the endometrium not being receptive. So, if your body is not accepting the embryo and resulting in recurrent implantation failure, it is important that you consider discussing the same issues with your fertility specialist.
4. IVF Cycle Cancellation
If you are wondering why IVF failed, the IVF cycle cancellation is one of the most crucial reasons behind the same. This is a condition wherein the ovary has lower reserves of developed follicles during the stimulation phase of the fertility treatment. This results in cancelled egg retrieval.
Statistics suggest that around 5-35% of women are poor responders when it comes to the health of their eggs and follicles in the ovaries. Any kind of underactive ovarian function plays a pivotal role in a failed IVF treatment.
IVF Cycle Cancellation leads to a delayed cycle. Although the cancellation of IVF cycles can be extremely disheartening and discouraging, it is always better to have a healthy fertilization and implantation procedure instead of experiencing another failure.
5. What to do After IVF Fails?
Now that you know the possible reasons behind IVF failure even with healthy embryos, it is important that you know what to do next. Although listening to your doctor talking about another failed IVF cycle can be extremely tough to hear, it is necessary that you let the specialist tell you about the issues and where you can go from there to ensure a successful conception.
Keep in mind that the next step in your IVF treatment journey after a failure is guided by the cause behind the failure.
Give Another Try - If this is your first failure at the IVF treatment, chances are that your infertility specialist will suggest undergoing another cycle of treatment.
Third-Party Donor - Another effective solution for failed IVF is to opt for a third-party donor. This is important in women who have poor quality eggs or issues with their ovarian functions. The donors are generally under the age of 30, anonymous, and screened before the procedure is done.
Surrogacy -In the case of IVF treatment that doesn’t work for you at all, your last resort might be surrogacy. It is a fairly expensive procedure and involves a lot of legal work too. So, ensure that you get all the details sorted before considering it.
With the progressing medical sciences, infertility treatments at Best IVF centre in Delhi, have now become a lot more accessible and mainstream for couples to opt for. If you are experiencing issues with your IVF treatment despite having good embryos, chances are that there are a few undiagnosed anomalies. Consult your doctor to find the cause and overcome it eventually.
At Mediworld, you will get the foremost fertility treatments and suggestions catered to you and your body’s needs.